Florence, Italy is known for its rich cultural heritage, artistic masterpieces, and architectural marvels. Some popular cultural city tours in Florence include:

1. Uffizi Gallery - One of the oldest art museums in the world, housing renowned works by Botticelli, Leonardo da Vinci, and Michelangelo.

2. Accademia Gallery - Home to Michelangelo's famous statue of David and several other notable works of art.

3. Cathedral of Santa Maria del Fiore (Duomo) - An iconic cathedral with a towering terracotta-tiled dome, offering panoramic views of the city.

4. Piazza della Signoria - A historic square that serves as a hub of cultural activity, featuring the Loggia dei Lanzi, a famous open-air sculpture gallery.

5. Palazzo Vecchio - A medieval palace that now serves as the city hall, with ornate architecture and paintings.

6. Ponte Vecchio - The old bridge over the Arno river, lined with jewelry shops and offering picturesque views.

These are some of the most popular cultural city tour destinations in Florence, but there are many more museums, churches, palaces, and landmarks that offer a glimpse into the city's rich history and cultural heritage.